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Fig. 4 | Molecular Medicine

Fig. 4

From: α-Ketoglutarate improves cardiac insufficiency through NAD+-SIRT1 signaling-mediated mitophagy and ferroptosis in pressure overload-induced mice

Fig. 4

AKG upregulated NAD levels in cardiomyocytes and increased SIRT1 expression. (A–C) The level of NAD+, NADH, and NAD+/NADH radio in the hearts of mice. (D–F) The level of NAD+, NADH, and NAD+/NADH radio in vitro cardiomyocytes. (G) Western blot analysis of β-MHC, SIRT1, and PINK1 in the hearts of mice. (H–J) Quantitative analysis of panel G. (K) Western blot analysis of SIRT1 in vitro cardiomyocytes. (L) Quantitative analysis of panel K. *P < 0.05, **P < 0.01, ***P < 0.001 vs. Sham/Control group; #P < 0.05, ##P < 0.01, ###P < 0.001 vs. TAC/AngII group

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Molecular Medicine

ISSN: 1528-3658