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Fig. 5 | Molecular Medicine

Fig. 5

From: α-Ketoglutarate improves cardiac insufficiency through NAD+-SIRT1 signaling-mediated mitophagy and ferroptosis in pressure overload-induced mice

Fig. 5

Effects of inhibiting SIRT1/PINK1 expression on myocardial hypertrophy. (A, F) Western blot analysis of protein SIRT1, PINK1, ANP and β-MHC after inhibiting SIRT1 expression (A) and PINK1 expression (F) in cardiomyocytes in vitro cardiomyocytes. (B–E) Quantitative analysis of panel A. (G–J) Quantitative analysis of panel F. (K) Real-time quantitative PCR analysis of SIRT1, PINK1, NPPA and MYH7 levels in cardiomyocytes. *P < 0.05, **P < 0.01, ***P < 0.001 vs. Sham/Control group; #P < 0.05, ##P < 0.01, ###P < 0.001 vs. AngII group; +P < 0.05, ++P < 0.01, +++P < 0.001 vs. AngII + AKG group

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Molecular Medicine

ISSN: 1528-3658