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Fig. 6 | Molecular Medicine

Fig. 6

From: α-Ketoglutarate improves cardiac insufficiency through NAD+-SIRT1 signaling-mediated mitophagy and ferroptosis in pressure overload-induced mice

Fig. 6

Blocking SIRT1/PINK1 abolished the AKG-mediated enhancement of mitophagy. (A) P62 expression in cardiomyocytes. (B) Quantitative analysis of panel A. (C) JC-1 staining fluorescence image of myocardial cells (reflecting the level of MMP, scale = 250 μm; enlarged scale = 50 μm). (D) Quantitative analysis of MMP, as shown by JC-1 staining (C). **P < 0.01, ***P < 0.001 vs. Control group; ##P < 0.01 vs. AngII group; ++P < 0.01, +++P < 0.001 vs. AngII + AKG group

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Molecular Medicine

ISSN: 1528-3658