Fig. 2

Core factors involved in sevoflurane-induced cognitive impairment identified by bioinformatics analysis. Note: (A) Heatmap showing the differentially expressed genes (DEGs) between standard control samples (Control group, n = 3) and sevoflurane-induced neurotoxicity rat samples (Sevo group, n = 3) in GSE141242 (LogFC > 0.5, P value < 0.05). (B) Functional enrichment analysis results of the DEGs at the biological process (BP), cellular component (CC), and molecular function (MF) levels. (C) Protein-protein interaction (PPI) network was constructed for the 128 encoded proteins of the DEGs identified in GSE141242. (D) Top 20 genes ranked by the number of connections in the PPI network. (E) The intersection between 43 DEGs (DIFF) identified in GSE141242 and genes associated with neurofibrillary tangles and protein phosphorylation. (F) Analysis of the differential expression of critical genes Fgf2 and Sgk1 using the Welch to test statistical method