Fig. 2

The RANKL/RANK signaling pathway activates NFATc1. RANKL binds to RANK, leading to the activation of downstream signaling pathways, including NF-κB and MAPK, through the involvement of TRAF6. The activated NF-κB and MAPK pathways mediate the expression of c-Fos and c-Jun, which in turn promote the activation of NFATc1. This activation of NFATc1 plays a crucial role in driving osteoclastogenesis, the formation and maturation of osteoclasts