Fig. 3

RANK collaborates with co-stimulatory receptors to facilitate the transmission of the Ca²⁺ signaling, sustaining the amplification of NFATc1. These co-stimulatory receptors include SIRPβ1, OSCAR, TREM-2, PIR-A, and FcRγ. When ITAM is phosphorylated, it binds to PLCγ2 and Syk, activating the immune receptors. Specifically, OSCAR and PIR-A bind to FcRγ, while TREM-2 and SIRPβ1 bind to DAP12. These interactions promote the transmission of the Ca²⁺ signaling and the subsequent amplification of NFATc1