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Fig. 4 | Molecular Medicine

Fig. 4

From: Recent advances of NFATc1 in rheumatoid arthritis-related bone destruction: mechanisms and potential therapeutic targets

Fig. 4

Bcl-6, IRF8, MafB, and Lhx2 negatively regulate the expression of NFATc1. In osteoclast differentiation, Bcl-6, IRF8, MafB, Lhx2, and ephrinB2 negatively regulate NFATc1 by inhibiting c-Fos expression. Blimp-1 can suppress the expression of Bcl-6, IRF8, MafB, and Lhx2. CTGF activate but CD11b inhibit Bcl-6. EEIG1 combines with Blimp-1 to downregulate IRF8. TUG1, miR-338-3p, and miR-199a-5p inhibit Maf8

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Molecular Medicine

ISSN: 1528-3658