Table 2 Diverse agents that regulate Ca²⁺-related signaling pathway in osteolclastogenesis

Citropten

Inhibited MAPK and PLCγ/Ca²⁺ signaling pathways

RAW264.7 cell

N/A

5–40 μM

N/A

Trang et al. (2023)

βBA

Inhibited the phosphorylation of Btk and PLCγ2

BMMs (ICR mice)

N/A

5–30 μM

N/A

Park et al. (2021)

BA

Attenuated the phosphorylation of PLCγ2-Ca²⁺ signaling pathway

BMMs (ICR mice)

ICR mice

1–10 μM

10 mg/kg

Jeong et al. (2020a)

Artesunate

Inhibited Ca²⁺ influx and decreased the expression of PP2B-Aα (calcineurin) and pPLCγ1

RAW264.7 cell

ICR mice

3.125–12.5 μM

10 mg/kg

Zeng et al. (2020)

Berberine hydrochloride

Reduced the expression of Ca²⁺-regulated phosphatase and PLCγ

RAW264.7 cell

N/A

5–20 μM

N/A

Ye et al. (2017)

Methyl gallate

Blocked the Akt and Btk-PLCγ2-Ca²⁺ signaling

BMMs (ICR mice)

ICR mice

1–10 μM

10 mg/kg

Baek et al. (2017)