Fig. 2

Prognostic value of ProstaTrend(-ffpe) in the FFPE biopsy cohort FFPE_Bx. We assessed the prognostic value of the ProstaTrend (A, C) and ProstaTrend-ffpe TRS (B, D) signature by Kaplan–Meier analysis and Cox proportional hazard regression (BCR as the primary endpoint). A, B Kaplan–Meier curves for patients with TRS > 0 (increased risk) compared to patients with TRS ≤ 0 (reduced risk). Color shades depict the 95% confidence intervals for Kaplan–Meier curves. The curves were truncated if the number of patients at risk dropped below 10 in both groups. The colored numbers above the x-axis indicate the number of patients at risk. Log-rank tests were performed to evaluate probabilities of BCR-free survival between these two groups. The numbers under the log-rank p-values indicate the number of patients and cases with BCR. C, D Univariate Cox-regression analysis for TRS on a continuous scale (top) and multivariable Cox-regression for TRS adjusted for Gleason grading group (GGG > 2) of the biopsies (bottom). logHR log hazard ratio, HR hazard ratio, CI confidence interval