Fig. 6From: Extracellular CIRP induces CD4CD8αα intraepithelial lymphocyte cytotoxicity in sepsisSummary of the findingseCIRP activates TLR4 to enhance the cytotoxicity of CD4CD8αα IELs as indicated by the increased production of GrB and Prf. Cytotoxic CD4CD8αα IELs induce IEC death, leading to intestinal injuryBack to article page