Fig. 2
From: BATF and BATF3 deficiency alters CD8+ effector/exhausted T cells balance in skin transplantation
BATF and BATF3 deficiency promotes long-term skin allograft survival. A Experimental design involving lymphopenic B6.Rag1−/− recipients adoptively co-transferred with equal numbers of WT CD8+ T cells, Batf−/− CD8+ T cells and Batf−/− Batf3−/− CD8+ T cells and grafted with BALB/c skin allografts. Tx, transplantation. B The percentage of graft survival post-allogeneic tail skin transplantation (n = 6). ***p < 0.001; Mann–Whitney test. C, D Representative images and H&E- stained images of rejected and accepted tail skin allografts posttransplant corresponding to (B). E PR scores of allograft tissue sections were evaluated on days 14 and days 100 after transplantation. **p < 0.01;***, p < 0.001