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Fig. 4 | Molecular Medicine

Fig. 4

From: BATF and BATF3 deficiency alters CD8+ effector/exhausted T cells balance in skin transplantation

Fig. 4

BATF and BATF3 deficiency inhibits functional differentiation of effector CD8+ T cells. A, B Representative contour plots and bar graphs showing the % of CD62L+PD-1-cells in co- transferred WT CD8+ T cells and Batf−/−Batf3−/−CD8+ T cells 14 days after skin transplants. Data are presented as means ± SD (n = 5) and are representative of three independent experiments. **, p < 0.01, ***, p < 0.001; unpaired Student’s t- test. C, D Representative contour plots and bar graphs show the % of CD127+KLRG-1-cells in spleen CD8+ T cells, ****, p < 0.0001. E, F FACS plots and bar graphs showing CXCR3 expression by co-transferred WT and batf−/− batf3−/− CD8+ T cells from skin transplant recipients. ***, p < 0.001

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