Fig. 1
From: Platelet-derived growth factor signaling in pericytes promotes hypothalamic inflammation and obesity
PDGF signaling in pericytes, but not in neurons, mediates the dysfunction of energy metabolism. A Pdgfb and Pdgfrb mRNA levels in the hypothalamus of Pdgfrb∆SYS-KO fed HFD for 4 weeks (n = 12–13). B Body weights of Pdgfrb∆SYS-KO (n = 12–13). C–E Metabolic parameters of Pdgfrb∆SYS-KO fed HFD for 3–4 weeks. Energy expenditure (C), locomotor activity (D) (n = 9–12), and food intake (E) (n = 4–5). F Pdgfrb mRNA levels in the hypothalamus of Pdgfrb∆CaMKII-KO fed HFD for 4 weeks (n = 8–10). G Body weights of Pdgfrb∆CaMKII-KO (n = 8–10). H Energy expenditure in Pdgfrb∆CaMKII-KO fed HFD for 3 weeks (n = 8–10). Data are presented as the mean ± SEM. *p < 0.05 and **p < 0.01