Fig. 2
Transcriptional sequencing analysis of potential drug resistance mechanisms in CRKP. A Volcano plots of gene expression in three KP strains and three CRKP strains. Orange dots represent upregulated genes, blue dots represent downregulated genes, and black dots represent non-differential genes. B Heatmap of differentially expressed genes between KP and CRKP strains. Orange represents upregulated genes, and blue represents downregulated genes. C The protein–protein interaction network of NDM-1 protein (Combined score = 0.7), with color ranging from yellow to red, indicates the Degree values of genes from small to large. D Bubble plot of KEGG pathway enrichment analysis of differentially expressed genes between KP and CRKP strains. E Bar chart of KEGG pathway enrichment analysis results related to beta-lactam resistance and associated pathways in differentially expressed genes between KP and CRKP strains. F The content related to Beta-lactam resistance and its associated pathways in the KEGG pathway enrichment analysis results (from the KEGG database at https://www.kegg.jp/kegg/pathway.html)