Fig. 5
In vitro Inhibition of CRKP Strain Virulence by Combined Treatment with IM and TH. A Impact of 25 μM IM, 0.4 μM TH, and the combination of 25 μM IM and 0.4 μM TH on the virulence of CRKP strains. B Western blot to detect changes in NDM-1 protein expression in CRKP strains after different drug treatments. C RT-qPCR to detect changes in blaNDM-1 gene expression in CRKP strains after different drug treatments. D Impact of IM, TH, and IM + TH on the survival rate of Galleria mellonella larvae infected with CRKP strains (n = 10). Quantitative data in the figure are represented as mean ± SD, with each experiment repeated 3 times. *P < 0.05 indicates significance between the two groups; ns indicates no difference between the two groups