Fig. 6

In vivo inhibition of CRKP strain virulence by combined treatment with IM and TH. A Illustration of mouse drug treatment. B Number of white blood cells and neutrophils in mouse blood after 7 days of IM, TH, and IM + TH treatment in CRKP-infected mice (n = 5). C Impact of IM, TH, and IM + TH on the survival rate of CRKP-infected mice (n = 10). D ELISA to detect the expression of inflammatory factors CRP, PCT, IL-1β, and IL-6 in mouse plasma after 7 days of IM, TH, and IM + TH treatment in CRKP-infected mice (n = 5). E Bacterial count in mouse lung tissue after 7 days of IM, TH, and IM + TH treatment in CRKP-infected mice (n = 5). F H&E Staining of mouse lung tissue after 7 days of IM, TH, and IM + TH treatment in CRKP-infected mice (scale bar: 200 μm, n = 5). Quantitative data in the figure are represented as mean ± SD, with each experiment repeated 3 times. *P < 0.05 indicates significance between the two groups; ns indicates no difference between the two groups