Fig. 6

Scleral THBS1 knockdown induced axial elongation and myopic refraction shift. A: Myopic refractive change was observed in mice of the THBS1 knockdown group at 28 days after AAV injection but not in Sham and Scramble groups. D, diopter. Each group n = 8, figure is an average of experiments, one-way ANOVA with Tukey post hoc test, ****p < 0.0001, NS: no significance. Bars represent mean ± standard deviations. B: Mice of THBS1 knockdown group showed more axial elongation than control group at 28 days after AAV injection. Each group n = 8, figure is an average of experiments, one-way ANOVA with Tukey post hoc test, *p < 0.05, NS: no significance. Bars represent mean ± standard deviations. C: No significant difference of choroidal thickness was found between the THBS1 knockdown, Sham or Scramble groups at 28 days after AAV injection. Each group n = 8, figure is an average of experiments, one-way ANOVA with Tukey post hoc test, NS: no significance. Bars represent mean ± standard deviations