Fig. 1

Artemisinin improves cognitive function and attenuates hippocampal neuronal loss in T2DM mice. T2DM mice were treated with artemisinin (Art, 40 mg/kg/d, i.p.) for 4 weeks. A Schematic diagram of Y-maze test. B The total number of times the mice entered the arms and (C) the alternation rate were analyzed in the Y maze test. D Schematic diagram of Morris water maze test. E The escape latency to find the platform in the navigation phase, F time spent in the target quadrant, and (G) the number of platform crossings during the probe trial phase in the MWM test were also analyzed. Data are expressed as the mean ± SEM (n = 12 per group). *P < 0.05, **P < 0.01 vs the control group; ^#P < 0.05 vs the T2DM group. H Statistical analyses for neuron number in the CA1 region. I Representative H&E staining images from the field CA1 region of the mice. Scale bar, 100 μm. The data are expressed as the mean ± SEM (n = 4 per group). *P < 0.05