Fig. 5

Cotreatment with ML385 or erastin abolishes the neuro-protective effect of Art on T2DM mice. T2DM mice were cotreated with artemisinin (Art, 40 mg/kg/d, i.p.) and ML385 (30 mg/kg, i.p.) or erastin (30 mg/kg, i.p.) for 4 consecutive weeks. Neuronal injury and neuron loss in the hippocampus were measured by H&E staining. A Representative images of the hippocampal CA1 region by H&E staining. Scale bar, 100 µm. B Statistical analyses for neuron number in the CA1 region. The data are expressed as the mean ± SEM (n = 4 per group). *P < 0.05