Fig. 6

Cotreatment with ML385 or erastin reverses the ameliorative effect of Art on cognitive deficits in T2DM mice. T2DM mice were cotreated with artemisinin (Art, 40 mg/kg/d, i.p.) and ML385 (30 mg/kg, i.p.) or erastin (30 mg/kg, i.p.) for 4 consecutive weeks. A Total entry times and (B) the alternation rate were detected in the Y maze test. C The escape latency to find the platform in the navigation phase, D time spent in the target quadrant and (E) number of platform crossings during the probe trial phase in the MWM test were also analysed. Data are the mean ± SEM (n = 12 per group). *P < 0.05 vs the T2DM + Art group