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Fig. 7 | Molecular Medicine

Fig. 7

From: WSB1, as an E3 ligase, restrains myocardial ischemia–reperfusion injury by activating β-catenin signaling via promoting GSK3β ubiquitination

Fig. 7

The effect of WSB1 on apoptosis was reversed by an inhibitor of β-catenin signaling. A The viability of myocardial cells with WSB1 overexpression and treatment of OGD/R and an inhibitor of β-catenin, PNU74654 was measured by CCK-8 assay. B and C The apoptosis of myocardial cells. D WSB1 played a protective role in cardiomyocytes by mediating the ubiquitination and degradation of GSK3β and inactivating β-catenin signaling under an ischemic condition. (OGD, oxygen-sugar deprivation; WSB1, WD repeat and SOCS box containing 1; PI, propidium iodide; GSK3β, glycogen synthase kinase 3 beta; **p < 0.01, ***p < 0.001)

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Molecular Medicine

ISSN: 1528-3658