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Fig. 4 | Molecular Medicine

Fig. 4

From: Iguratimod, an allosteric inhibitor of macrophage migration inhibitory factor (MIF), prevents mortality and oxidative stress in a murine model of acetaminophen overdose

Fig. 4

T-614 prevents oxidative stress in APAP overdose. (A) Experimental summary. (B) C57BL/6 wild-type and (C) MIF KO mice (n = 4–7/group) were given 300/kg APAP intraperitoneally in addition to doses of intraperitoneal T-614 or vehicle (1 h pre- and post-APAP) and euthanized at 4 h for tissue collection and H2O2 assay as described in Materials and Methods. Results are shown as mean ± SD and were analyzed using unpaired t-tests with one-tailed p-values given: *, p < 0.05. T614 = iguratimod

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Molecular Medicine

ISSN: 1528-3658