Fig. 6
From: Hypothalamic POMC neuron-specific knockout of MC4R affects insulin sensitivity by regulating Kir2.1
Knockdown of Kir2.1 reversed the effect of MC4R deficiency on energy balance and insulin resistance in HFD-treated mice. (A) Body-weight in MC4R-ko mice injected with AAV-Kir2.1 or sh-NC. (B) Food intake in MC4R-ko mice injected with AAV-Kir2.1 or sh-NC. (C and D) Fat mass at 21 wk old. (E and F) O2 consumption (VO2), (G and H) CO2 production, and (I and J) RER of the mice fed an HFD. (K and L) Energy expenditure was evaluated of the mice. (M and N) GTT (M) and the AUC of GTT (N) of 21-wk-old mice. (O and P) ITT (O) and the AUC of ITT (P) of 21-wk-old mice. *P < 0.05, **P < 0.01. Two-tailed Student’s t test was used for comparison for two groups