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Fig. 4 | Molecular Medicine

Fig. 4

From: Ginsenoside Rh2 shifts tumor metabolism from aerobic glycolysis to oxidative phosphorylation through regulating the HIF1-α/PDK4 axis in non-small cell lung cancer

Fig. 4

G-Rh2 inhibited distal tumor metastasis in vivo. (A, B) Live imaging illustrating the effects of G-Rh2 on A549 cell metastasis 14 days after tail vein injection. (C) Differential expression of epithelial–mesenchymal transition associated proteins detected by western blot assays. (D-F) The number of metastatic foci in lung tissues, calculated based on HE staining. Data are expressed as means ± SD. (G-I) Representative images showing A549 tumor invasion in a plantar lymphatic metastasis nude mouse model, and live imaging and immunofluorescence detection of CD31 expression showing the effect of G-Rh2 on A549 tumor invasion 2 weeks after tail vein injection. Data are expressed as mean ± SD. **P < 0.01, ***P < 0.001, ****P < 0.001 vs. the control group

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Molecular Medicine

ISSN: 1528-3658