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Fig. 4 | Molecular Medicine

Fig. 4

From: CHMP5 attenuates osteoarthritis via inhibiting chondrocyte apoptosis and extracellular matrix degradation: involvement of NF-κB pathway

Fig. 4

CHMP5 suppressed IL-1β-stimulated pro-apoptosis in the chondrocytes. (A) Expression of CHMP5 in the chondrocytes treated with IL-1β for different times was tested by real time PCR and western blot. ***P < 0.001 versus the 0 h group. ###P < 0.001 versus the 6 h group. (B) CHMP5 overexpression restored but (C) CHMP5 knockdown exacerbated the repression of chondrocyte viability induced by IL-1β. (D) CHMP5 overexpression reversed IL-1β-activated pro-apoptotic effect. (E) CHMP5 silencing promoted the effect. (F) The expression of cleaved caspase-3 and cleaved PARP were detected by western blot. *P < 0.05. **P < 0.01. ***P < 0.001

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Molecular Medicine

ISSN: 1528-3658