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Fig. 6 | Molecular Medicine

Fig. 6

From: CHMP5 attenuates osteoarthritis via inhibiting chondrocyte apoptosis and extracellular matrix degradation: involvement of NF-κB pathway

Fig. 6

IL-1β-activated NF-κB pathway was restrained by CHMP5 in the chondrocytes. (A) The protein contents of IκBα, p-p65 and p65 were quantified in the chondrocytes by western blot. (B) CHMP5 reversed IL-1β-stimulated increase of p65 expression in the nucleus and decrease of p65 expression in the cytoplasm. (C) CHMP5 bound with IκBα and USP15 proteins in the chondrocytes. (D) CHMP5 decreased the ubiquitination of IκBα in the chondrocytes. (E) Silencing CHMP5 downregulated IκBα levels in the chondrocytes with the addition of IL-1β

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Molecular Medicine

ISSN: 1528-3658