Skip to main content
Fig. 6 | Molecular Medicine

Fig. 6

From: Elk1 enhances inflammatory cell infiltration and exacerbates acute lung injury/acute respiratory distress syndrome by suppressing Fcgr2b transcription

Fig. 6

Downregulation of Elk1 increases Fcgr2b level to alleviate the infiltration of Th17 cells and lung tissue injury in ARDS rats. Notes A, RT-qPCR to examine Elk1 and Fcgr2b expression in lung tissues of ARDS rats; B, HE staining to evaluate the pathomorphology of lung tissues of ARDS rats; C, immunohistochemistry to measure RORγt expression in lung tissues of ARDS rats; D, flow cytometry to detect the proportion of Th17 cells in BALF of ARDS rats; E, ELISA to determine IL-17 and IL-6 expression in BALF of ARDS rats; F, the PaO2/FiO2 ratio of ARDS rats; G, the lung W/D weight ratio of ARDS rats; H, the protein concentration in BALF of ARDS rats (n = 6/group). Differences among multiple groups were compared using one-way (C-H) or two-way (A) analysis of variance with Tukey’s post-hoc test. ARDS, acute respiratory distress syndrome; PaO2/FiO2, arterial partial pressure of oxygen/fraction of inspired oxygen; W/D, wet/dry; BALF, bronchoalveolar lavage fluid

Back to article page

Molecular Medicine

ISSN: 1528-3658