Figure 1
From: Requirement of STAT3 Activation for Differentiation of Mucosal Stratified Squamous Epithelium
Immunolocalization of K13 and phospho-STAT3 in papilloma tissue and human normal laryngeal tissue. Immunohistochemistry staining of formalin-fixed, paraffin-embedded normal laryngeal and papilloma tissues. Tissue sections were incubated with K13 monoclonal antibody (A, B), phospho-STAT3 antibody (C, D), total STAT3 (E, F), or control antibody (G, H). Note the presence of very little K13 in the cytoplasm of papillomas and very little phospho-STAT3 in the nucleus of papillomas. Also note that abundant K13 was detected in the cytoplasm of normal laryngeal tissue, and phospho-STAT3 was detected in the nuclei of almost all layers. Control staining does not show significant staining. Arrow indicates basement membrane. Hematoxylin counterstain. Bar, 24 µm.