Table 1 Up-regulation of specific gene expression in human vascular endothelial cells treated with interleukin-4

Adhesion molecules

VCAM1

NM_001078

21.7

<0.001

Vascular cell adhesion molecule 1

CSPG2

D32039

5.4

0.006

Chondroitin sulfate proteoglycan 2

SELE

NM_000450

4.3

<0.001

E-selectin

AIM1

U83115

4.1

<0.001

Absent in melanoma 1

AGC1

X17406

3.2

0.002

Aggrecan 1

PCDH7

NM_002589

2.7

<0.001

BH-protocadherin

FCN3

NM_003665

2.2

0.023

Ficolin (collage/fibrinogen domain) 3

FAT

NM_005245

2.0

0.007

FAT tumor suppressor homolog 1

Chemokines and cytokines

CCL2

S69738

8.2

<0.001

Monocyte chemoattractant protein-1

IL6

NM_000600

2.0

0.003

Interleukin-6

Apoptosis

PAWR

NM_002583

2.6

0.001

PRKC, apoptosis, WT1, regulator

CASP3

NM_004346

2.5

0.008

Caspase 3

CASP2

AF314174

2.0

0.028

Caspase 2

Signal transduction

PMCH

NM_002674

331.2

<0.001

Promelanin-concentrating hormone

PIK3CG

AF327656

9.9

0.013

Phosphoinositide-3-kinase, catalytic, γ

SOCS1

AB005043

5.8

<0.001

Suppressor of cytokine signaling 1

LIFR

NM_002310

5.7

<0.001

Leukemia inhibitory factor receptor

BMP4

D30751

3.4

<0.001

Bone morphogenetic protein 4

CSF2RB

AV756141

3.2

<0.001

Colony stimulating factor 2 receptor β

KIAA0551

AF172268

3.2

<0.001

Traf2 and NCK interacting kinase

RGS2

NM_002923

3.1

<0.001

Regulator of G-protein signaling 2

INHBA

M13436

3.0

<0.001

Inhibin βA

MET

BG170541

2.7

0.003

Hepatocyte growth factor receptor

RICS

NM_014715

2.3

0.045

Rho GTPase-activating protein

H11

AF133207

2.2

0.002

Protein kinase H11

BMP2

NM_001200

2.2

<0.001

Bone morphogenetic protein 2

GUCY1B3

W93728

2.1

0.010

Guanylate cyclase 1, soluble, β3

EXT1

NM_000127

2.0

<0.001

Exostoses (multiple) 1

ARL7

NM_005737

2.0

0.005

ADP-ribosylation factor-like 7

Transcription factors

CREM

D14826

8.5

0.004

cAMP responsive element modulator

PKNOX2

AK023792

6.2

0.001

PBX/knotted 1 homeobox 2

MAD

NM_002357

5.4

<0.001

MAX dimerization protein 1

FOXC1

AU145890

4.6

0.011

Forkhead box C1

CITED2

NM_006079

4.2

<0.001

Cbp/p300-interacting transactivator

IRLB

BE268538

4.1

<0.001

c-Myc promoter-binding protein

CEBPB

AL564683

2.9

<0.001

CCAAT/enhancer binding protein β

POU4F1

NM_006237

2.6

0.005

POU domain, class 4, transcription factor 1

GATA6

D87811

2.3

0.018

GATA binding protein 6

KIAA0146

NM_005195

2.3

<0.001

CCAAT enhancer binding protein (CEBP)

SSRP2

NM_012446

2.2

0.003

Single-stranded DNA binding protein 2

ELL2

NM_012081

2.1

0.022

ELL-related RNA polymerase II, elongation factor

KLF4

BF514079

2.1

0.011

Kruppel-like factor 4

TRAP95

NM_005481

2.0

0.038

Thyroid hormone receptor-associated protein, 95-kD subunit

CART1

NM_006982

2.0

0.024

Cartilage paired-class homeoprotein 1

TOX

AI961231

2.0

0.009

Thymus high mobility group box protein

Others

MCHP

S64288

204.2

<0.001

Melanin-concentrating hormone precursor

HS3ST1

BF000296

10.7

0.002

Heparan sulfate 3-O-sulfotransferase 1

CDC45L

NM_003504

7.4

0.003

CDC45 cell division cycle 45-like

SIAT8A

L32867

6.5

<0.001

Sialyltransferase 8A

TMOD1

NM_003275

5.9

0.004

Tropomodulin 1

MTHFR

AJ249275

5.7

0.009

5, 10-Methylenetetrahydrofolate reductase

ENPP1

NM_006208

5.2

0.004

Ectonucleotide pyrophosphatase/phosphodiesterase 1

LOX

NM_002317

5.1

<0.001

Lysyl oxidase

AMIGO4

AC004010

4.2

<0.001

Amphoterin induced gene 2

SULF1

AW043713

4.6

<0.001

Sulfatase 1

GJA5

NM_005266

4.3

<0.001

Gap junction protein (Connexin 40)

ARK5

NM_014840

3.9

<0.001

KIAA0537 gene product

FKBP5

NM_004117

3.8

0.002

FK506 binding protein 5

LRRTM2

NM_015564

3.8

0.017

Leucine-rich repeat transmembrane neuronal 2 protein

COVA1

NM_006375

3.6

0.014

Cytosolic ovarian carcinoma antigen 1

DACT1

NM_016651

3.6

<0.001

Dapper homolog 1, antagonist of β-catenin

DMD

NM_004010

3.6

<0.001

Dystrophin

LRRN3

AI221950

3.5

0.006

Leucine rich repeat neuronal 3

PTX3

NM_002852

3.5

<0.001

Pentaxin-related gene

CLCN4

AA071195

3.5

0.006

Chloride channel 4

SLC38A1

NM_030674

3.5

<0.001

Amino acid transporter system A1

FLJ11743

NM_024527

3.5

0.011

Hypothetical protein FLJ11743

OSPBL11

NM_022776

3.4

<0.001

Oxysterol binding protein-like 11

CH25H

NM_003956

3.2

0.026

Cholesterol 25-hydroxylase

FBN1

AI264196

2.8

0.003

Fibrillin 1 (Marfan syndrome)

ELAVL2

NM_004432

2.7

<0.001

ELAV (embryonic lethal, abnormal vision)-like 2

CPT2

M58581

2.7

0.020

Carnitine palmitoyltransferase II

NNMT

NM_006169

2.5

<0.001

Nicotinamide N-methyltransferase

UP

NM_003364

2.5

<0.001

Uridine phosphorylase

KCNK3

NM_002246

2.5

0.022

Potassium channel, subfamily K, member 3

DAAM1

AK021890

2.5

<0.001

Dishevelled associated activator of morphogenesis 1

SLC22A4

NM_003059

2.4

<0.001

Solute carrier family 22, member 4

PSCD1

NM_004762

2.4

<0.001

Cytohesin 1

JAG1

NM_000214

2.4

0.024

Jagged 1 (Alagille syndrome)

EGLN3

NM_022073

2.4

0.007

Egl 9 homolog 3

TPK1

NM_022445

2.3

0.005

Thiamin pyrophosphokinase 1

LOC169611

AL050002

2.3

0.004

Hypothetical protein LOC169611

PVRL3

AA129716

2.3

0.004

Poliovirus receptor-related 3

DOK5

AL050069

2.2

0.002

Docking protein 5

MRF2

BG285011

2.2

<0.001

Modulator recognition factor 2

DNAJC3

NM_006260

2.2

0.034

DnaJ (Hsp40) homolog, subfamily C, 3

CPR8

AK022459

2.2

0.005

Cell cycle progression 8 protein

SIAT1

AV695711

2.1

0.002

Sialyltransferase 1

RDX

NM_002906

2.1

0.024

Radixin

CYP1B1

NM_000104

2.0

0.010

Cytochrome P450 1B1

ALDH1A2

NM_003888

2.0

0.002

Aldehyde dehydrogenase1A2

GCNT1

NM_001490

2.0

<0.001

β-1,6-N-acetylglucosaminyltransferase

Unknown

DKK2

NM_014421

26.5

<0.001

Dickkopf homolog 2

T12479

AW029169

8.5

<0.001

Hypothetical protein DKFZp 564N1362.1

FLJ10713

NM_018189

5.0

<0.001

Hypothetical protein FLJ10713

KIAA0977

NM_014900

3.8

<0.001

KIAA0977 protein

LOC51334

NM_016644

2.8

0.010

Mesenchymal stem cell protein DSC54

CGI-115

NM_016052

2.6

<0.001

CGI-115 protein

C13orf7

NM_024546

2.4

<0.001

Chromosome 13 open reading frame 7

FLJ20378

AI336206

2.2

<0.001

Hypothetical protein FLJ20378

SCA1

NM_000332

2.2

0.012

Spinocerebellar ataxia 1

FLJ90005

W27419

2.1

<0.001

Hypothetical protein FLJ90005

24739

AF070571

2.1

0.011

Homo sapiens clone 24739

FJX1

NM_014344

2.1

0.007

Four jointed box 1

FLJ10901

NM_018265

2.0

0.020

Hypothetical protein FLJ10901

HRASLS

NM_020386

2.0

0.002

HRAS-like suppressor

Housekeeping genes

ACTB

Hs.426930

1.0

0.694

β-Actin

GAPDH

M33197

1.0

0.680

Glyceraldehyde-3-phosphate dehydrogenase