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Figure 3 | Molecular Medicine

Figure 3

From: Reduced Peripheral PGE2 Biosynthesis in Plasmodium falciparum Malaria Occurs through Hemozoin-Induced Suppression of Blood Mononuclear Cell Cyclooxygenase-2 Gene Expression via an Interleukin-10-Independent Mechanism

Figure 3

Effect of hemozoin and β-hematin on PGE2 production. PBMCs (1 × 106 cells/mL) were stimulated with media alone, LPS (100 ng/mL) and IFN-γ (200 U/mL), and LPS and IFN-y in the presence of hemozoin (10, 1.0, and 0.1 µg/mL) or β-hematin (10, 1.0, and 0.1 µg/mL). Supernatants were removed at 48 and 72 h for PGE2 determination. Values are the mean ± SEM, n = 18. Data are expressed as percent change over LPS and IFN-γ stimulation. Statistical significance was determined by the Kruskal-Wallis test. *P < 0.05.

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Molecular Medicine

ISSN: 1528-3658