Figure 4

Serum glucose, insulin levels, and C-peptide/insulin ratio in fasting WT and adhesion receptor-deficient mice. A: Serum insulin concentration did not decrease significantly in ICAM-1-deficient mice after 24 h of fasting (P > 0.05), whereas it did in WT mice (P < 0.01). Each experimental group had 7 to 10 mice. Statistical analysis was performed using Kruskal-Wallis test (nonparametric ANOVA) followed by Dunn’s multiple comparisons test. B: Blood glucose concentration decreased more profoundly in ICAM-1-deficient (P < 0.01) and CD18-deficient mice (P < 0.01) than in WT mice. Each group had 6 to 10 mice. Statistical analysis was performed using Tukey-Kramer multiple comparisons test followed by Bartlett’s standard deviation normality test and Kolmogorov and Smirnov gaussian normality test. C: Serum C-peptide/insulin molar ratio after 24 h of fasting is significantly higher in WT mice than in ICAM-1-deficient mice (P < 0.05). Each experimental group had 5 to 6 mice. Statistical analysis was performed using unpaired t test followed by normality post-test.