Figure 4
From: The Role of AEBP1 in Sex-Specific Diet-Induced Obesity
Estrogen/ER modulates AEBP1 expression in vivo and in vitro. (A) The average values of AEBP1 expression in WAT from sham-operated (SHAM, n = 6), ovariectomized (OVX, n = 5), or estradiol-injected OVX (OVX + E2, n = 6) mice are represented as mean ± SEM. *P < 0.05 compared with sham-operated mice. (B) Dose-dependent repression of luciferase activity by ERα. Each data point represents the mean ± SEM luciferase activity measured in duplicate dishes for 4 independent experiments. The values are normalized with β-galactosidase activity. (C) Dose-dependent activation of the luciferase activity by ERβ. Each data point represents the mean ± SEM luciferase activity measured in duplicate dishes for 3 independent experiments. The values are normalized with β-galactosidase activity. (D) Inhibition of the ERa repression activity on the reporter expression by ERβ. Each data point represents the mean ± SEM luciferase activity measured in duplicate dishes for 2 independent experiments. The values are normalized with β-galactosidase activity.