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Table 1 Selected modules for liver cancer dataset and NCI60 dataset.

From: Peeling Off the Hidden Genetic Heterogeneities of Cancers Based on Disease-Relevant Functional Modules

Datasets

BP categorya

CC categoryb

P (module)c

N d

ARIe

Sf

P (ARI)g

Liver cancer

GO:0006955: immune response

GO:0005576: extracellular

< 2.22E-16

82

0.830

8

< 0.001

 

GO:0007275: development

GO:0005576: extracellular

< 2.22E-16

127

0.871

6

< 0.001

 

GO:0008151: cell growth and/or maintenance

GO:0005576: extracellular

2.90E-11

139

0.892

5

< 0.001

 

GO:0007165: signal transduction

GO:0005576: extracellular

7.78E-10

104

0.790

10

< 0.001

 

GO:0006810: transport

GO:0005887: integral to plasma membrane

1.05E-06

168

0.713

14

< 0.001

 

GO:0007186: G-protein coupled receptor protein signaling pathway

GO:0005623: cell

1.05E-04

133

0.850

7

< 0.001

Majority rule

NAh

NA

NA

NA

0.934

3

< 0.001

Top150_liver

NA

NA

NA

150

0.871

6

< 0.001

NCI60

GO:0007155: cell adhesion

GO:0005886: plasma membrane

1.07E-08

77

0.585

8

< 0.001

 

GO:0009653: morphogenesis

GO:0016020: membrane

6.30E-08

112

0.481

14

0.010

 

GO:0007155: cell adhesion

GO:0016021: integral to membrane

1.01E-07

87

0.649

11

< 0.001

 

GO:0007275: development

GO:0016021: integral to membrane

2.25E-06

104

0.596

14

< 0.001

 

GO:0007165: signal transduction

GO:0016021: integral to membrane

6.42E-05

180

0.715

10

< 0.001

 

GO:0007166: cell surface receptor linked signal transduction

GO:0016021: integral to membrane

2.13E-04

106

0.580

11

< 0.001

 

GO:0006955: immune response

GO:0005623: cell

8.16E-04

133

0.640

9

< 0.001

Majority rule

NA

NA

NA

NA

0.697

8

< 0.001

Top150_NCI

NA

NA

NA

150

0.728

7

< 0.001

  1. aThe biological process description of the module; bthe cellular component description of the module; cstatistical significance of the selected module; dnumber of annotated genes; eadjusted Rand index; fnumber of misallocated samples; gStatistical significance of ARI with exclusion of genes; hnot available.