Table 2 Selected genes differentially expressed in PsA versus control analyses.

Increased expression

Pro-inflammatory genes

S100 calcium binding protein A8 (calgranulin A)

6279

66247.22

126617.96

60370.74

0.00030

1.91

S100 calcium binding protein A12 (calgranulin C)

6283

7604.28

23690.10

16085.82

0.00002

3.12

Thioredoxin (TXN)

7295

964.60

2541.18

1576.58

0.00058

2.63

Apoptosis regulator and remover of apoptotic cells

CD36 antigen (collagen type I receptor, thrombospondin

948

2498.94

4625.22

2126.28

0.00004

1.85

receptor)

Caspase 5, apoptosis-related cysteine protease

838

470.27

768.19

297.92

0.00082

1.63

Apoptotic protease activating factor

317

1205.06

1824.54

619.48

0.00026

1.51

Proliferation and cell cycle regulators

Putative lymphocyte G₀/G₁ switch gene

50486

670.46

1174.83

504.37

0.00007

1.75

Tumor protein p53-binding protein

10210

548.71

976.09

427.38

0.00009

1.78

Other genes

LYN

4067

16212.88

25824.29

9611.41

0.00037

1.59

PTPRF interacting protein, binding protein 1 (liprin beta 1)

8496

512.91

1110.50

597.59

0.00082

2.17

DORA reverse strand protein 1 (DREV1)

51108

6514.16

10604.53

4090.36

0.00003

1.63

Immunoglobulin superfamily, member 6

10261

3568.95

5944.85

2375.90

0.00045

1.67

Reduced expression

MAP kinase pathway

Protein kinase C binding protein 1

23613

2490.32

1408.96

−1081.36

1.96×10⁻⁰⁹

−1.77

Mitogen-activated protein kinase kinase kinase

4215

9968.25

2725.36

−7242.89

2.56×10⁻⁰⁸

−3.66

3 (MAP3K3)

Protein kinase C, beta 1 (PKCB1)

5579

15980.18

10215.49

−5764.69

6.72×10⁻⁰⁷

−1.56

Guanine nucleotide binding protein, alpha inhibitor

2771

13325.14

5815.91

−7509.23

2.53×10⁻⁰⁶

−2.29

activity polypeptide 2 (GNAI2)

Mitogen-activated protein kinase kinase kinase kinase

11184

4436.88

2419.86

−2017.02

3.12×10⁻⁰⁶

−1.83

1 (MAP4K1)

Tumor necrosis factor receptor superfamily, member 7

939

7068.02

4239.03

−2828.99

0.000014

−1.67

(CD27)

Protein kinase C zeta (PKCζ)

5590

2120.71

1288.08

−832.63

0.000016

−1.65

Transcription factor 7 (T-cell specific, HMG-box)

6932

1963.48

976.09

−987.39

0.000028

−2.01

TNFRSF1A-associated via death domain (TRADD)

8717

2762.66

1559.04

−1203.63

0.00034

−1.77

Mitogen-activated protein kinase kinase 5 (MEK5

5607

636.21

250.88

−385.33

0.0004

−2.54

or MAP2K5)

Dynactin 1 (p150, glued homolog, Drosophila)

1639

1203.40

717.34

−486.06

0.00043

−1.68

Tumor suppression, cell cycle regulation and proliferation

Forkhead box O1A (rhabdomyosarcoma)

2308

4630.12

1713.26

−2916.86

3×10⁻⁰⁸

−2.70

Ras association (RalGDS/AF-6) domain family 1

11186

2902.84

1643.79

−1259.05

7.98×10⁻⁰⁷

−1.77

Tumor suppressor deleted in oral cancer-related

10263

1559.28

920.44

−638.84

0.00002

−1.69

1 (CDK2AP2)

Cyclin D3

896

20631.00

13226.92

−7404.08

0.000029

−1.56

Cell division cycle 25B

994

8988.00

5770.62

−3217.38

0.000034

−1.56

MCM5 minichromosome maintenance deficient 5

4174

1146.18

645.93

−500.25

0.00046

−1.77

Signal-induced proliferation-associated gene 1 (SIPA1)

6494

3595.89

2185.49

−1410.40

0.00081

−1.65

Tumor protein p53 (Li-Fraumeni syndrome)

7157

876.10

424.12

−451.98

0.0006

−2.07

Cyclin-dependent kinase 9 (CDC2-related kinase) (CDK9)

1025

1233.65

660.32

−573.33

0.0001

−1.87

Minichromosome maintenance deficient 5 (S. cerevisiae)

4174

1146.18

645.93

−500.25

0.00046

−1.77

(MCM5)

Anaphase-promoting complex subunit 2 (ANAPC2)

29882

1395.85

827.77

−568.08

0.00084

−1.69

B cells

B lymphoid tyrosine kinase (BLK)

640

753.22

207.33

−545.88

1.2×10⁻⁰⁷

−3.63

B-cell associated protein (PHB2)

11331

14897.88

9669.92

−5227.96

2.2×10⁻⁰⁶

−1.54

Immunoglobulin heavy constant µ

3507

12491.85

5911.85

−6580.01

3.2×10⁻⁰⁷

−2.11

Immunoglobulin heavy constant δ, IGHδ

3495

1321.20

710.12

−611.08

0.00062

−1.86

Immunoglobulin κ constant

3514

45808.52

23671.46

−22137.06

7.6×10⁻⁰⁶

−1.94

CD81 antigen

975

6766.15

3812.25

−2953.90

0.000029

−1.77

CD72 antigen

971

1197.51

679.37

−518.13

0.00037

−1.76

CD79B antigen

974

1991.54

1287.24

−704.31

0.00043

−1.55

Ubiquitination

Ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog,

7327

2243.79

740.21

−1503.59

2.34x10⁻⁰⁹

−3.03

yeast)

Ubiquitin specific protease 11

8237

3558.94

1886.54

−1672.41

3.38×10⁻⁰⁸

−1.89

Ubiquitin-activating enzyme E1-like

7318

4071.51

2517.64

−1553.86

0.00042

−1.62

Regulation of immune responses and transcription

Signal transducer and activator of transcription 3 (STAT3)

6774

27432.17

16069.52

−11362.65

0.000031

−1.71

Single Ig IL-1R-related molecule (SIGIRR), TOLL/IL1R 8 (TIR8)

59307

2318.33

1312.86

−1005.46

0.000056

−1.77

Caspase recruitment domain 4 (CARD4 or NOD1)

10392

2841.76

1795.15

−1046.62

0.000044

−1.58

Inhibitor of k light polypeptide gene enhancer in B-cells,

3551

1404.94

887.24

−517.70

0.00012

−1.58

kinase β (IκBKβ)

Interleukin 11 receptor α (IL-11RA)

3590

1684.05

1052.81

−631.24

0.00017

−1.60

Protein tyrosine phosphatase, non-receptor type 6 (SHP1)

5777

20430.79

12753.10

−7677.69

0.000098

−1.60

Runt-related transcription factor 3 (RUNX3)

864

7168.09

3720.07

−3448.02

1.5×10⁻⁰⁶

−1.93

Others

Nucleoporin 62 kDa (NUP62)

23636

1288.71

470.93

−817.78

2.29×10⁻¹⁰

−2.74

Major histocompatibility complex, class I, E (HLA-E)

3133

98505.23

63128.26

−35376.97

3.4×10⁻⁰⁸

−1.56

Lipin 1

23175

2360.67

1175.61

−1185.06

0.00011

−2.01