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Figure 7 | Molecular Medicine

Figure 7

From: The Histone Deacetylase Inhibitor ITF2357 Reduces Production of Pro-Inflammatory Cytokines In Vitro and Systemic Inflammation In Vivo

Figure 7

Effect of ITF2357 on LPS-induced IFNγ production. Freshly obtained PBMCs were preincubated for 1 h with increasing concentrations of ITF2357 (horizontal axis) and stimulated with LPS (10 ng/mL) for 24 h. Levels of secreted IFNγare shown in ng/mL on the vertical axis. The data are presented as the mean percent change ± SEM of 4 donors and the dashed line indicates inhibition of 50%. *P < 0.05; **P < 0.01 from LPS only.

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