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Table 1 Inhibition of Maize HDAC by ITF2357

From: The Histone Deacetylase Inhibitor ITF2357 Reduces Production of Pro-Inflammatory Cytokines In Vitro and Systemic Inflammation In Vivo

Compound

HD2

HD1-B

HD1-A

ITF2357

10a

7.5

16

ITF2363b

1150

420

300

ITF2375c

NA

NA

NA

  1. aInhibitory concentration of 50% in nM.
  2. bChemical name 4-aminobenzohydroxamic acid.
  3. cInactive metabolite of ITF2357.
  4. NA indicates no activity.
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Molecular Medicine

ISSN: 1528-3658