Figure 1
From: Indole-3-Carbinol Prevents PTEN Loss in Cervical Cancer In Vivo
Inhibition of PTEN expression during the development of cervical cancer in humans and in HPV16 transgenic mice. (A) Human condyloma, low-grade cervical dysplasia, high-grade cervical dysplasia, and cervical carcinoma specimens were stained with H&E or immunostained by PTEN monoclonal antibody A2B1 (PTEN) and visualized under low-power (×100) or high-power (×400) magnification. (B) Tissue sections of normal, low-grade dysplasia, high-grade dysplasia, and carcinoma from HPV16 transgenic mice were stained and visualized as in panel A. Images are representative of more than 20 specimens per group.