Figure 2
From: Indole-3-Carbinol Prevents PTEN Loss in Cervical Cancer In Vivo
I3C promotes PTEN expression in HPV16 transgenic mice. HPV-16 transgenic mice and their nontransgenic littermates were given slow-release estrogen to promote dysplasia and fed diets with or without I3C. Cervix sections were prepared and immunostained with PTEN monoclonal antibody A2B1. Controls (no I3C treatment) are high-grade dysplasia. Specimens from the I3C-treated groups are age-matched. Images are representative of 20 per category. Magnification ×100 and ×400.