Figure 3
From: Indole-3-Carbinol Prevents PTEN Loss in Cervical Cancer In Vivo
Quantitation confirms inhibition of PTEN expression during development of cervical cancer, and I3C increases PTEN expression. Imaging and quantitation of PTEN immunohistochemistry were done on a minimum of 3 tissues per group for cervix specimens from humans (A) and mice (B) with varying degrees of pathology. Quantitation of PTEN (C) was performed on specimens from nontransgenic and K14HPV16 transgenic mice treated with estradiol (E2) and diets with and without I3C from 5 weeks to 7 months of age. *P ≤ 0.05.