Figure 1

Serum HMGB1 concentrations in trauma victims with hemorrhagic shock and healthy human volunteers (n = 9). Blood samples from the trauma victims were obtained as soon as possible after admission to the Emergency Department and always < 6 h after the time of injury (n = 25) and again the next day (i.e., approximately 24 h after injury; n = 24). Serum HMGB1 concentrations in the trauma victims at either time point were significantly greater than the values measured in the healthy subjects (P < 0.0001).