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Table 1 Effect of treatment with anti-HMGB1 antibody on several parameters measured at 4 h after HS/R or the sham procedure in mice.

From: Anti-HMGB1 Neutralizing Antibody Ameliorates Gut Barrier Dysfunction and Improves Survival after Hemorrhagic Shock

Parameter

Normal

Sham

IgG

aHMGB1

n

6

6

6

6

FD4 clearance (nL min−1 cm−1)

14 ±1

24 ± 2a

35 ± 6b

29 ± 6

Bacterial translocation (CFU/g)

17 ± 17

374 ± 251a

258 ± 216

241 ± 198

Serum IL-6 concentration (pg/mL)

0 ±0

49 ±8a

360 ± 161b

262 ± 54b

Serum IL-10 concentration (pg/mL)

7 ±2

19 ±5a

173 ± 35b

193 ± 40b

Serum ALT concentration (pg/mL)

40 ± 2

55 ± 4

130 ± 22b

103 ± 20b

  1. aP< 0.05 sham vs. normal; bP < 0.05 IgG vs. sham. None of the contrasts between the IgG and aHMGB1 groups were statistically significant.