Figure 2

Data and model output for plasma IL-6 and IL-10 In wild-type and CD14^−/− mice subjected to LPS. Wild-type (C57Bl/6; 3—8 per time point) and CD14^−/− (4 per time point) mice were injected with 3 m/kg of E. coli LPS. IL-6 and IL-10 (symbols, showing mean ± SEM) were measured as described in “Materials and Methods.” For wild-type mice (A and C), the line indicates the output of the baseline (wild-type) model of acute inflammation (9). For CD14^−/− mice (B and D), model recalibration was carried out as described in “Materials and Methods,” yielding an ensemble of 5 models (lines). “Best Model” indicates the model giving the best overall qualitative fit to the data as judged by investigator consensus.