Figure 3

Data and model output for plasma IL-6 and IL-10 in wild-type and CD14^−/− mice subjected to cannulation or hemorrhagic shock. Wild-type (C57Bl/6; 7 per time point) and CD14^−/− (5 per time point) mice were subjected to cannulation or hemorrhagic shock as described in “Materials and Methods.” IL-6 (A) and IL-10 (B) were measured as described in “Materials and Methods” and are shown as mean ± SEM. Black bars: wild-type mice; open bars: CD14^−/− mice. C and D indicate the output of the ensemble of mathematical models, showing simulated levels of IL-6 and IL-10, respectively. Black bars: output of baseline (wild-type) model of inflammation (9); open bars, output of the ensemble of 5 CD14^−/−-specific models of inflammation (shown as mean ± SEM).