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Figure 8 | Molecular Medicine

Figure 8

From: MyD88 and Src Are Differentially Regulated in Kupffer Cells of Males and Proestrus Females Following Hypoxias

Figure 8

A schematic model for sex difference in TLR signaling pathways. Hypoxia induced an increase in Kupffer cell TLR4 expression in both males and females. In female mice (right side) both MyD88 and Src are downregulated; independent pathways are stimulated. In males while MyD88 is not expressed, the expression and phosphorylation of Src, on the other hand, is significantly increased following hypoxia. The differential regulation of MyD88 and Src in males and females following hypoxia is likely to contribute differential expression of IL-6 in Kupffer cells from males and females.

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Molecular Medicine

ISSN: 1528-3658