Figure 1

A. The Zn²⁺ -dependent Ca²⁺ rise triggered in HaCaT, keratinocytic cell line, is insensitive to the general tyrosine kinase inhibitor genistein. B. A model for ZnR signaling mediating Zn²⁺ -dependent cell growth and survival. Our results indicate that a ZnR is the major link between changes in extracellular Zn²⁺ and physiological cell function, such as: secretion, proliferation and survival. Desensitization, induced by Zn²⁺, largely attenuates the Zn²⁺ -dependent signaling.