A. The Zn2+ -dependent Ca2+ rise triggered in HaCaT, keratinocytic cell line, is insensitive to the general tyrosine kinase inhibitor genistein. B. A model for ZnR signaling mediating Zn2+ -dependent cell growth and survival. Our results indicate that a ZnR is the major link between changes in extracellular Zn2+ and physiological cell function, such as: secretion, proliferation and survival. Desensitization, induced by Zn2+, largely attenuates the Zn2+ -dependent signaling.