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Figure 1 | Molecular Medicine

Figure 1

From: The Zinc Sensing Receptor, a Link Between Zinc and Cell Signaling

Figure 1

A. The Zn2+ -dependent Ca2+ rise triggered in HaCaT, keratinocytic cell line, is insensitive to the general tyrosine kinase inhibitor genistein. B. A model for ZnR signaling mediating Zn2+ -dependent cell growth and survival. Our results indicate that a ZnR is the major link between changes in extracellular Zn2+ and physiological cell function, such as: secretion, proliferation and survival. Desensitization, induced by Zn2+, largely attenuates the Zn2+ -dependent signaling.

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