Figure 6

CEPO-treated animals have significantly less necrosis within the targeted brain volume. (A) Lesion size at the center of the necrosis volume in representative animals from the saline and CEPO groups 90 days after the delivery of radiation. Inner dashed circle indicates the delivery of 90 to 100 Gy. Difference between outer and inner circles indicates a region receiving between 50 and 90 Gy. Note that CEPO treatment was associated with a marked reduction in injury within the lower dose range. Distances between slices is 200 µm; scale bar, 1 mm. (B) Mean volume of necrosis in the CEPO-treated group was half of that observed for the saline treatment group. (C) Representative photomicrographs comparing lesions of the 2 treatment groups. Animals that received saline generally possessed dense calcification (arrow) in contrast to the less affected CEPO group. Original magnification ×40.