Figure 5
From: Nonhematopoietic Erythropoietin Derivatives Prevent Motoneuron Degeneration In Vitro and In Vivo
ASIALO-EPO and CEPO treatments both reduce the astroglial (GFAP) and microglial (CD11b) activation in cervical spinal cord of wobbler mice. Representative picture of GFAP and CD11b immunostaining in the cervical region of 12-week-old control (A-D) and wobbler (E-P) mice. Wobbler mice were treated with CEPO (I-L) or ASIALO-EPO (M-P) (32 µg/kg intraperitoneally 3 times a week) or vehicle (E-H) starting from 4 weeks of age. Scale bar: 100 µm.