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Table 1 Clinical and demographic characteristics of patients

From: SERCA2a, Phospholamban, Sarcolipin, and Ryanodine Receptors Gene Expression in Children with Congenital Heart Defects

 

TOF (23 pts)

VSD (10 pts)

ASD (13 pts)

P

Age (years)

2.6 ± 0.8

1.3 ± 0.4

3.4 ± 0.5

ns

Sex F (n, %)

7 (30.4)

5 (50.0)

6 (46.1)

ns

PFOa (n, %)

18 (78.3)

6(60)

ns

Enlarged RA (n, %)b

19(82.6)

10 (100)

13 (100)

ns

Severely enlarged RA (n, %)b

0 (0)

1 (10)

9 (69.2)

0.04 vs ASD

SaturationO2

81.0 ± 5.7

96.2 ± 1.5

95.6 ± 1.9

< 0.0001

RAP (mmHg)c

5.9 ± 2.4

4.7 ±1.6

5.2 ± 2.4

ns

RVP Sys (mmHg)

72.1 ± 5.2

76.7 ± 10.9

32.4 ± 3.6

< 0.0001 vs ASD

  1. a Echo data were available for all patients. F, females; RA, right atrium; RAP, right atrium pressure; RVP, right ventricle pressure. A patent foramen ovalis (PFO) was considered to be present when described in the echo referral or in the surgical report In 17 out of 18 patients with TOF and PFO, a right to left shunt was present. In the latter the shunt across the PFO was bidirectional. Five patients with VSD had a left to right shunt across the PFO.
  2. bThe right atrium was described as “enlarged” by the surgeon in all 46 patients. Echocardiographic data are reported in the table.
  3. cPreoperative cardiac catheterization was performed in 12 (52.1%) patients with TOF, 3 (30.0%) patients with VSD and 5 (38.5%) patients with ASD. In ASD patients, cardiac catheterization was always performed in concomitance with an attempt at percutaneous closure of the defect.