Figure 4From: Phosphorothioate Oligonucleotides Reduce PrPSc Levels and Prion Infectivity in Cultured CellsPrP reduction in the presence of PS-DNA can be blocked by preincubation with anti-PrP Fabs. N2a cells were incubated with 20 mg/mL of the indicated Fab for 6 h followed by incubation with 4 µM 22-mer PS-DNA for 6 h. The following Fabs that recognize different epitopes of PrP were used: E149, R72, R1, D13 and D18 (15). C, control, no antibody.Back to article page