Table 1 Bioassays of prions in ScN2a cells treated with 22-mer PS-DNA
From: Phosphorothioate Oligonucleotides Reduce PrPSc Levels and Prion Infectivity in Cultured Cells
Host | Inoculum | Length of experiment (days) | Mean incubation period ± SEM (days) | n/n 0 a |
|---|---|---|---|---|
CD-1 | ScN2a cells | — | 148 ± 2 | 10/10 |
CD-1 | ScN2a cells treated with PS-DNA for 8 weeks | > 600 | 305 ± 50 | 5/6 |
Tg(MoPrP-A)4053 | ScN2a cells | — | 68 ± 2 | 10/10 |
Tg(MoPrP-A)4053 | ScN2a cells treated with PS-DNA for 8 weeks | > 400 | - | 0/6 |